15. Segment and Geographic Information

The Company has one operating and reporting segment which primarily focuses on the development and commercialization of novel therapeutics to treat serious unmet medical needs. The Company has determined that the chief executive officer is the chief operating decision maker (“CODM”). The CODM assesses performance of the business, monitors budget versus actual results and manages and allocates resources to the Company’s operations using consolidated net income (loss) as the primary measurement. The CODM is regularly provided with entity-wide expense categories that are consistent with those found on the Company’s consolidated statements of operations. These significant segment expenses include cost of goods sold, research and development expenses, selling, general and administrative expenses, and restructuring charge. Other segment items that are presented on the consolidated statements of operations include interest expense, loss on debt extinguishments, interest income and other income (expense), net, and provision for (benefit from) income taxes. The measure of segment assets is reported on the balance sheet as total consolidated assets.

Supplemental enterprise-wide information is presented below.

Geographic Revenues

Geographic revenues, which are based on the region that revenue is generated, are as follows (in thousands):

 

 

 

Years Ended December 31,

 

 

2025

 

 

2024

 

 

United States

 

$

 

 

$

26,114

 

 

Europe

 

 

5,643

 

 

 

6,270

 

 

Japan

 

 

797

 

 

 

(2,854

)

 

China

 

 

 

 

 

91

 

 

Total revenue

 

$

6,440

 

 

$

29,621

 

 

 

Customer Concentration

The Company’s revenues have been generated from the following collaboration partners that individually accounted for 10% or more of the Company’s total revenue:

 

 

 

Percentage of Revenue

 

 

 

Years Ended December 31,

 

 

 

2025

 

 

2024

 

AstraZeneca

 

 

%

 

 

88

%

Astellas

 

 

100

%

 

 

12

%

Historical Timeline

Fiscal YearFiled
2025Mar 16, 2026Showing above
2024Mar 17, 2025
2023Feb 26, 2024
2022Feb 27, 2023
2021Feb 28, 2022
2020Mar 1, 2021
2019Mar 2, 2020
2018Feb 27, 2019
2017Feb 27, 2018
2016Mar 1, 2017
2015Feb 29, 2016

About Segments Disclosures

Segment disclosures break a company into its reportable operating units, revealing revenue, profit, and asset allocation that consolidated financial statements obscure. Under ASC 280, segments must match how the chief operating decision maker views the business, providing a window into internal management structure and resource allocation priorities.

Key signals: compare segment margins to identify which units drive profitability and which destroy value. Watch for changes in the number of reportable segments — segment aggregation or disaggregation often coincides with strategic shifts or attempts to obscure declining performance. Intersegment elimination patterns reveal internal pricing practices. The reconciliation between segment totals and consolidated figures exposes corporate overhead allocation and unallocated items. Geographic revenue concentration highlights regulatory and currency exposure. Compare segment-level capital expenditure against segment revenue to assess where management is investing for future growth versus harvesting existing assets.