3. Segment reporting

Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision-maker (CODM), the Company's Chief Executive Officer, in making decisions regarding resource allocation and assessing performance. The Company views its operations and manages its business in one operating segment. When evaluating the Company's financial performance, the CODM reviews total expenses and expenses by function. Further, the CODM reviews the segment's assets based on total assets reported on the consolidated balance sheet.

The table below is a summary of the segment loss, including significant segment expenses (in thousands):

 

 

 

Twelve months ended December 31,

 

 

 

2025

 

 

2024

 

 

2023

 

 

 

 

 

 

 

 

 

 

 

Operating expenses:

 

 

 

 

 

 

 

 

 

Research, development, and laboratory

 

$

45,696

 

 

$

86,522

 

 

$

112,567

 

Facility costs

 

 

44,253

 

 

 

49,429

 

 

 

54,778

 

Support functions

 

 

29,425

 

 

 

45,587

 

 

 

54,355

 

Stock-based compensation

 

 

25,464

 

 

 

37,678

 

 

 

35,533

 

Technical operations and manufacturing

 

 

21,813

 

 

 

39,713

 

 

 

52,359

 

Portfolio prioritization costs

 

 

318

 

 

 

5,840

 

 

 

5,203

 

Other(1)

 

 

9,307

 

 

 

14,944

 

 

 

20,313

 

Research and development related success payments and contingent consideration

 

 

29,432

 

 

 

(8,881

)

 

 

(48,981

)

Impairment of long-lived assets

 

 

44,611

 

 

 

1,891

 

 

 

7,014

 

Total operating expenses

 

 

250,319

 

 

 

272,723

 

 

 

293,141

 

Loss from operations

 

 

(250,319

)

 

 

(272,723

)

 

 

(293,141

)

Interest income, net

 

 

3,848

 

 

 

10,471

 

 

 

9,938

 

Other income (expense), net

 

 

2,305

 

 

 

(4,507

)

 

 

(52

)

Net loss

 

$

(244,166

)

 

$

(266,759

)

 

$

(283,255

)

(1) Other segment expenses include licensing costs, consulting fees, business taxes, and insurance costs for the years ended December 31, 2025, 2024, and 2023, and costs incurred for the early termination of the Fremont lease for the year ended December 31, 2023.

Historical Timeline

Fiscal YearFiled
2025Mar 3, 2026Showing above
2024Mar 17, 2025

About Segments Disclosures

Segment disclosures break a company into its reportable operating units, revealing revenue, profit, and asset allocation that consolidated financial statements obscure. Under ASC 280, segments must match how the chief operating decision maker views the business, providing a window into internal management structure and resource allocation priorities.

Key signals: compare segment margins to identify which units drive profitability and which destroy value. Watch for changes in the number of reportable segments — segment aggregation or disaggregation often coincides with strategic shifts or attempts to obscure declining performance. Intersegment elimination patterns reveal internal pricing practices. The reconciliation between segment totals and consolidated figures exposes corporate overhead allocation and unallocated items. Geographic revenue concentration highlights regulatory and currency exposure. Compare segment-level capital expenditure against segment revenue to assess where management is investing for future growth versus harvesting existing assets.