Segment Information
The Company manages its operations as a single segment. The Company’s CODM, its Chief Executive Officer, manages the Company's operations on a consolidated basis for the purposes of assessing performance and making operating decisions. The segment measure of profit or loss is consolidated net income (loss).
The following table presents selected financial information with respect to the Company's single operating segment for the years ended:

Year Ended December 31,
20252024
Collaboration revenue$25,421 $210,782 
Less:
Research and development expenses
Direct research and development expenses
ENTR-601-4424,340 13,109 
ENTR-601-4516,772 8,584 
ENTR-601-507,694 10,851 
ENTR-601-518,622 1,345 
Collaboration services2,463 12,074 
Ocular programs
1,962 2,960 
Other preclinical and discovery2,672 4,966 
Unallocated research and development expenses
Personnel related (including stock-based compensation)48,246 41,762 
Facility related and other29,498 29,655 
Total research and development expenses142,269 125,306 
General and administrative expenses41,05038,465
Interest and other income15,07219,474
Provision for income taxes924 (859)
Net (loss) income
$(141,902)$65,626 
Assets regularly provided to the CODM are consistent with those reported on the consolidated balance sheets with particular emphasis on the Company’s available liquidity, including its cash, cash equivalents and marketable securities balances. All of the Company’s tangible assets are held in the United States.

Historical Timeline

Fiscal YearFiled
2025Feb 26, 2026Showing above
2024Feb 27, 2025

About Segments Disclosures

Segment disclosures break a company into its reportable operating units, revealing revenue, profit, and asset allocation that consolidated financial statements obscure. Under ASC 280, segments must match how the chief operating decision maker views the business, providing a window into internal management structure and resource allocation priorities.

Key signals: compare segment margins to identify which units drive profitability and which destroy value. Watch for changes in the number of reportable segments — segment aggregation or disaggregation often coincides with strategic shifts or attempts to obscure declining performance. Intersegment elimination patterns reveal internal pricing practices. The reconciliation between segment totals and consolidated figures exposes corporate overhead allocation and unallocated items. Geographic revenue concentration highlights regulatory and currency exposure. Compare segment-level capital expenditure against segment revenue to assess where management is investing for future growth versus harvesting existing assets.