10. INCOME TAXES

 

For financial reporting purposes, loss before provision for income taxes includes the following components (in thousands):

 

 

Year Ended December 31,

 

 

 

2025

 

 

2024

 

 

2023

 

Domestic

 

$

(299,614

)

 

$

(152,147

)

 

$

(95,989

)

Foreign

 

 

 

 

 

 

 

 

 

Loss before income taxes

 

$

(299,614

)

 

$

(152,147

)

 

$

(95,989

)

 

Income Taxes Paid

 

The following table presents income taxes paid, net of refunds received (in thousands):

 

 

Year Ended December 31,

 

 

 

2025

 

 

2024

 

 

2023

 

U.S. State and Local:

 

 

 

 

 

 

 

 

 

California

 

 

1

 

 

 

1

 

 

 

1

 

New Jersey

 

 

1

 

 

 

 

 

 

 

Massachusetts

 

 

15

 

 

 

 

 

 

 

Total income taxes paid

 

$

17

 

 

$

1

 

 

$

1

 

 

Provision for Income Taxes

Current and deferred provision for income taxes was de minimis for the years ended December 31, 2025, 2024, and 2023.

A reconciliation of the provision for income taxes computed using the U.S. statutory federal income tax rate compared to the income tax provision included in the statement of operations and comprehensive loss is as follows (in thousands):

 

 

Year Ended December 31,

 

 

 

2025

 

 

%

 

 

2024

 

 

%

 

 

2023

 

 

%

 

Tax at U.S. statutory rate on income before income taxes

 

$

(62,919

)

 

 

21.00

%

 

$

(31,951

)

 

 

21.00

%

 

$

(20,158

)

 

 

21.00

%

State income taxes, net of federal effect

 

 

(166

)

 

 

0.06

%

 

 

(210

)

 

 

0.14

%

 

 

(122

)

 

 

0.13

%

Change in valuation allowance

 

 

64,058

 

 

 

-21.38

%

 

 

34,448

 

 

 

-22.64

%

 

 

21,250

 

 

 

-22.14

%

Nontaxzable or nondeductible items:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Stock based compensation

 

 

(1,132

)

 

 

0.38

%

 

 

(1,965

)

 

 

1.29

%

 

 

485

 

 

 

-0.51

%

Other

 

 

1,160

 

 

 

-0.39

%

 

 

762

 

 

 

-0.50

%

 

 

21

 

 

 

-0.02

%

Tax credits:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Federal research & development credits

 

 

(1,618

)

 

 

0.54

%

 

 

(1,618

)

 

 

1.06

%

 

 

(2,015

)

 

 

2.10

%

Worldwide changes in unrecognized tax benefits

 

 

554

 

 

 

-0.19

%

 

 

535

 

 

 

-0.35

%

 

 

540

 

 

 

-0.56

%

Other

 

 

64

 

 

 

-0.02

%

 

 

 

 

 

0.00

%

 

 

 

 

 

0.00

%

Provision for income taxes

 

$

1

 

 

 

0.00

%

 

$

1

 

 

 

0.00

%

 

$

1

 

 

 

0.00

%

 

For the years ended December 31, 2025, 2024, and 2023, state and local income taxes in California comprise the majority of the state and local income taxes, net of federal effect category.

 

Deferred Tax Assets and Liabilities

 

Deferred tax assets and liabilities are determined based on the differences between financial reporting and income tax bases of assets and liabilities, as well as net operating loss carryforwards and are measured using the enacted tax rates and laws in effect when the differences are expected to reverse. The significant components of the Company’s net deferred tax assets and liabilities are as follows (in thousands):

 

 

December 31,

 

 

 

2025

 

 

2024

 

 

2023

 

Deferred tax assets:

 

 

 

 

 

 

 

 

 

Federal and state net operating loss carryforward

 

$

84,624

 

 

$

38,736

 

 

$

27,539

 

Research and other credits

 

 

10,330

 

 

 

8,190

 

 

 

6,051

 

Capitalized research & development

 

 

59,062

 

 

 

46,225

 

 

 

25,264

 

Fixed assets

 

 

30

 

 

 

5

 

 

 

3

 

Reserves and accruals

 

 

916

 

 

 

1,310

 

 

 

755

 

Stock based compensation

 

 

9,809

 

 

 

4,311

 

 

 

2,978

 

Other intangibles

 

 

7,141

 

 

 

7,641

 

 

 

8,313

 

Other deferred tax assets

 

 

406

 

 

 

400

 

 

 

384

 

Lease liability

 

 

521

 

 

 

831

 

 

 

804

 

Total gross deferred tax assets

 

 

172,839

 

 

 

107,649

 

 

 

72,091

 

Less: valuation allowance

 

 

(172,267

)

 

 

(106,857

)

 

 

(71,372

)

Total deferred tax assets

 

 

572

 

 

 

792

 

 

 

719

 

Deferred tax liabilities:

 

 

 

 

 

 

 

 

 

Right of use

 

 

(406

)

 

 

(709

)

 

 

(619

)

Other deferred tax liabilities

 

 

(166

)

 

 

(83

)

 

 

(100

)

Total gross deferred tax liabilities

 

 

(572

)

 

 

(792

)

 

 

(719

)

Net deferred tax assets

 

$

 

 

$

 

 

$

 

 

As of December 31, 2025, the Company has federal and state net operating loss carryforwards of $389.9 million and $42.3 million, respectively, of which $10.2 million of federal net operating loss carryforwards and $37.0 million of state net operating carryforwards will begin expiring in the year 2032 and 2036, respectively, if not utilized. The Company also has $379.6 million of federal net operating loss carryforwards as of December 31, 2025 that do not expire. The Company has $8.6 million of federal research and development tax credit carryforwards, which begin to expire in the year 2037. The Company has $4.3 million of state research and development tax credit carryforwards, which have no expiration date.

Utilization of the federal and state net operating loss and tax credit carryforwards may be subject to a substantial annual limitation due to the “change in ownership” provisions of the Internal Revenue Code of 1986. The annual limitation may result in the expiration of net operating losses and credits before utilization. The Company has not performed an analysis to determine if such ownership changes have occurred. An analysis will be performed prior to recognizing the benefits of any losses or credits in the financial statements.

Management assesses the available positive and negative evidence to estimate if sufficient future taxable income will be generated to use the existing deferred tax assets. Based on the weight of all evidence including a history of operating losses, management has determined that it is not more likely than not that the net deferred tax assets will be realized. A valuation allowance of $172.3 million and $106.9 million as of December 31, 2025 and 2024, respectively, has been established to offset the deferred tax assets as realization of such assets is uncertain.

As required under ASU 2023-09, the Company has included only the portion of the valuation allowance related to federal deferred tax assets in the “change in valuation allowance” line of the rate reconciliation. The following table presents a reconciliation of the total change in the valuation allowance (in thousands):

 

 

Year Ended December 31,

 

 

 

2025

 

 

2024

 

 

2023

 

Beginning balance

 

$

106,857

 

 

$

71,372

 

 

$

49,648

 

Change charged to income tax expense

 

 

65,492

 

 

 

35,460

 

 

 

21,871

 

Changes charged to other comprehensive income

 

 

(82

)

 

 

25

 

 

 

(147

)

Ending balance

 

$

172,267

 

 

$

106,857

 

 

$

71,372

 

 

Uncertain Tax Benefits

 

The Company has the following activity relating to the gross amount of unrecognized tax benefits (in thousands):

 

 

Year Ended December 31,

 

 

 

2025

 

 

2024

 

 

2023

 

Beginning balance

 

$

2,048

 

 

$

1,513

 

 

$

941

 

Additions based on tax positions related to prior year

 

 

63

 

 

 

 

 

 

 

Additions based on tax positions related to current year

 

 

535

 

 

 

535

 

 

 

572

 

Ending balance

 

$

2,646

 

 

$

2,048

 

 

$

1,513

 

 

During the years ended December 31, 2025, 2024, and 2023, no interest or penalties were required to be recognized relating to unrecognized tax benefits.

The Company accounts for income taxes in accordance with authoritative accounting guidance which states the impact of an uncertain income tax position is recognized at the largest amount that is “more likely than not” to be sustained upon audit by the relevant taxing authority. An uncertain tax position will not be recognized if it has less than a 50% likelihood of being sustained. None of these uncertain tax positions will impact the Company’s effective tax rate if assessed. The Company’s policy is to classify interest and penalties associated with unrecognized tax benefits as income tax expense.

The Company files income tax returns in the U.S. and various states. The Company is not currently under examination by any major tax jurisdictions nor has it been in the past. Because of net operating losses and research credit carryovers, substantially all of our tax years remain open to examination. Although it is reasonably possible that certain unrecognized tax benefits may increase or decrease within the next 12 months due to tax examination changes, settlement activities, expirations of statute of limitations, or the impact on recognition and measurement considerations related to the results of published tax cases or other similar activities, the Company does not anticipate any significant changes to unrecognized tax benefits over the next 12 months.

About Income Taxes Disclosures

The income tax disclosure reveals how much a company actually pays in taxes versus what the statutory rate would predict. Analysts focus on the effective tax rate (ETR) reconciliation, which breaks down every item driving the gap between the 21% federal rate and the company's reported ETR — including R&D credits, foreign rate differentials, and state taxes. Deferred tax assets (DTAs) and their valuation allowances signal management's confidence in future profitability: a rising allowance suggests the company doubts it can use accumulated tax benefits. Uncertain tax benefit (UTB) reserves quantify exposure to IRS challenges on aggressive positions.

Key signals to watch: sudden ETR drops without clear operational reasons, large increases in valuation allowances, growing UTB balances, and significant unremitted foreign earnings. Post-TCJA, pay attention to GILTI and BEAT provisions that affect multinational tax structures. Compare the cash taxes paid (from the cash flow statement) against the income tax provision to gauge earnings quality.