Property, plant and equipment, net consist of the following (in thousands):
December 31,
Generally Used Estimated Useful Life20252024
Clinical and manufacturing equipment
Up to 13 years
$848,473 $871,827 
Building
20 years
524,608 529,716 
Leasehold improvements
Lease term 1
67,402 62,172 
Computer software and hardware3 years120,608 135,756 
Land57,868 63,875 
Furniture, fixtures and other
2-5 years
151,874 135,816 
Construction in progress127,944 133,684 
Total1,898,777 1,932,846 
Less: Accumulated depreciation and impairment charges (767,324)(661,712)
Total property, plant and equipment, net$1,131,453 $1,271,134 
1    Shorter of the remaining lease term or the estimated useful lives of the assets.

Historical Timeline

Fiscal YearFiled
2025Feb 27, 2026Showing above
2020Feb 26, 2021
2019Feb 28, 2020
2018Feb 28, 2019
2017Feb 28, 2018

About PP&E Disclosures

The PP&E disclosure details a company's physical asset base — land, buildings, machinery, and equipment — along with the depreciation methods and useful life assumptions that determine how these costs flow through the income statement. Capitalization policy thresholds reveal management's judgment on the boundary between expense and asset, directly affecting both reported earnings and asset values.

Key signals: changes in estimated useful lives or depreciation methods can materially shift reported earnings without any operational change. Compare capital expenditures against depreciation expense — when capex consistently trails depreciation, the asset base may be aging and underinvested. Watch for large asset impairments or write-downs that signal overvalued carrying amounts. Asset retirement obligations reveal future environmental or decommissioning costs that are often underappreciated. Compare PP&E intensity (PP&E-to-revenue) against industry peers to assess capital efficiency and competitive positioning.