PRODUCT REVENUE
To date, our primary source of product revenue has been from the U.S. sales of RYTELO, which we began
shipping to our customers in June 2024. To date, product revenue pursuant to NPPs outside of the U.S. have been not
material.
The reconciliation of gross product sales to net product sales by each significant category of gross-to-net
adjustments was as follows for the years ended December 31, 2025 and 2024:
Year Ended December 31,
(in thousands)
2025
2024
Gross product revenue
$223,112
$89,418
Gross-to-net adjustments:
Chargebacks
(25,525)
(8,724)
Distributor service fees
(7,512)
(3,048)
Government rebates
(2,603)
(926)
Sales returns and allowances
(3,849)
(225)
Total gross-to-net adjustments
$(39,489)
$(12,923)
Product revenues, net
$183,623
$76,495
As of December 31, 2025, three customers individually accounted for approximately 45%, 32% and 21% of
our gross accounts receivable associated with our product revenue, as compared to 43%, 38% and 17% as of December 31,
2024, respectively.

Historical Timeline

Fiscal YearFiled
2025Mar 2, 2026Showing above
2024Feb 27, 2025

About Revenue Disclosures

Revenue disclosures under ASC 606 explain how a company identifies performance obligations, allocates transaction prices, and determines when revenue is recognized. This section is essential for understanding whether reported revenue reflects genuine economic activity or aggressive accounting choices. Analysts examine the mix of point-in-time versus over-time recognition, which directly affects revenue timing and comparability.

Key signals: rising contract liabilities (deferred revenue) suggest strong future revenue visibility, while declining contract assets may indicate slowing project milestones. Watch for variable consideration estimates — rebates, returns, and performance bonuses that require management judgment. Significant changes in disaggregated revenue by geography or product line can reveal shifting business mix before it appears in headline numbers. Compare revenue growth against contract liability growth to assess sustainability, and scrutinize any changes in the timing of recognition that coincide with earnings pressure.