SEGMENT REPORTING
We are currently developing therapies for the treatment of hematologic malignancies. To date, our only
source of product revenue has been from U.S. sales of RYTELO, which began shipping to customers in June 2024.
Additionally, we have generated insignificant royalty and license fee revenue under agreements that out-license technology
to various companies.
For the year ended December 31, 2025, we have identified one operating and reportable segment. We
define our operating segments based on internally reported financial information that is regularly reviewed by the Chief
Operating Decision Maker or CODM to analyze financial performance, make decisions, and allocate resources. Our Chief
Executive Officer is the CODM.
The CODM reviews the segment's profit or loss based on net (loss) income reported on the consolidated
statement of operations and comprehensive (loss) income and considers forecast-to-actuals variances on a quarterly basis
for expenses that are deemed significant. Further, the CODM reviews the segment's assets based on total assets reported on
the consolidated balance sheet. All long-lived assets are held in the U.S. Further, the CODM reviews the segment's assets
based on total assets reported on the consolidated balance sheet. All long-lived assets are held in the United States.
Our CODM views specific categories within research and development expenses and selling, general and
administrative expenses as significant given the correlation between cash burn and profitability. The following table
reconciles reported revenues to net (loss) income under the significant expense principle for the year ended December 31,
2025 and 2024:
Year Ended December 31,
(in millions)
2025
2024
Revenues:
Product revenue, net
183.6
76.5
Royalties
0.3
0.5
Total revenues
$183.9
$77.0
Operating expenses:
Cost of goods sold
4.7
1.3
Research and development
Research and clinical expenses
54.2
67.9
Chemistry, manufacturing, and control expenses
9.8
26.2
Restructuring charges
8.6
Selling, general and administrative
Commercial expenses
78.6
72.0
Restructuring charges
8.4
Other segment expenses*
88.2
83.3
Total operating expenses
$252.5
$250.7
Loss from operations
(68.6)
(173.7)
Total interest and other income (expense)
(14.9)
(0.9)
Net loss
$(83.5)
$(174.6)
*Other segment expenses includes stock-based compensation expense and other general and administrative expenses
largely resulting from personnel costs for individuals in administrative functions and legal and professional fees.
Accordingly, the Company consists of a single operating and reportable segment and the consolidated financial statements
and notes thereto are presented as a single reportable segment.

Historical Timeline

Fiscal YearFiled
2025Mar 2, 2026Showing above
2024Feb 27, 2025
2015Mar 10, 2016

About Segments Disclosures

Segment disclosures break a company into its reportable operating units, revealing revenue, profit, and asset allocation that consolidated financial statements obscure. Under ASC 280, segments must match how the chief operating decision maker views the business, providing a window into internal management structure and resource allocation priorities.

Key signals: compare segment margins to identify which units drive profitability and which destroy value. Watch for changes in the number of reportable segments — segment aggregation or disaggregation often coincides with strategic shifts or attempts to obscure declining performance. Intersegment elimination patterns reveal internal pricing practices. The reconciliation between segment totals and consolidated figures exposes corporate overhead allocation and unallocated items. Geographic revenue concentration highlights regulatory and currency exposure. Compare segment-level capital expenditure against segment revenue to assess where management is investing for future growth versus harvesting existing assets.