Property and equipment, net, consisted of the following (in thousands):
December 31,
20242023
Leasehold improvements
$79,613 $118,319 
Laboratory equipment
36,106 33,368 
Computer equipment and software
1,805 1,672 
Furniture and fixtures
1,114 814 
Construction in progress
241 128 
Property and equipment, at cost
118,879 154,301 
Less: Accumulated depreciation and amortization
(70,679)(51,647)
Total property and equipment, net
$48,200 $102,654 

About PP&E Disclosures

The PP&E disclosure details a company's physical asset base — land, buildings, machinery, and equipment — along with the depreciation methods and useful life assumptions that determine how these costs flow through the income statement. Capitalization policy thresholds reveal management's judgment on the boundary between expense and asset, directly affecting both reported earnings and asset values.

Key signals: changes in estimated useful lives or depreciation methods can materially shift reported earnings without any operational change. Compare capital expenditures against depreciation expense — when capex consistently trails depreciation, the asset base may be aging and underinvested. Watch for large asset impairments or write-downs that signal overvalued carrying amounts. Asset retirement obligations reveal future environmental or decommissioning costs that are often underappreciated. Compare PP&E intensity (PP&E-to-revenue) against industry peers to assess capital efficiency and competitive positioning.