12. Segment Information

The Company operates under one reportable business segment, providing discovery research technology to enable the discovery of next-generation therapeutics. The determination of a single reportable business segment is consistent with the consolidated financial information regularly provided to the Company’s chief operating decision maker (“CODM”). The Company’s CODM is its Chief Executive Officer, who reviews financial information presented on a consolidated basis for purposes of making operating decisions, allocating resources, and evaluating financial performance.

In addition to the significant expense categories included within the consolidated statements of operations, certain other disaggregated amounts that comprise research and development and general and administrative are reviewed by the CODM. These expenses consist of (1) personnel related expenses, including salaries, benefits and share-based compensation, (2) external expenses, including third-party costs for goods and services such as lab supplies and contract research, and (3) facility and other overhead expenses, including depreciation and occupancy costs.

The following table outlines information about segment revenues, significant segment expenses, and segment net loss for the years ended December 31, 2025 and 2024:
(in thousands)Year Ended December 31,
20252024
Revenue
$18,666 $26,391 
Cost of xPloration revenue
303 — 
Research and development expenses
Personnel related expenses
23,123 28,336 
External expenses
13,276 17,698 
Facility and other overhead expenses
11,355 9,076 
   Total research and development expenses
47,754 55,110 
General and administrative expenses
Personnel related expenses20,934 21,841 
External expenses7,392 7,931 
Facility and other overhead expenses889 969 
   Total general and administrative expenses
29,215 30,741 
Amortization of intangibles
12,912 17,407 
Other operating expense (income), net
(2,549)(2,365)
Total other income, net
2,675 3,091 
Income tax benefit
1,515 9,378 
Net loss
$(64,779)$(62,033)
All long-term assets are maintained in, and all net losses are attributable to, the United States of America.

Historical Timeline

Fiscal YearFiled
2025Mar 4, 2026Showing above
2024Mar 18, 2025

About Segments Disclosures

Segment disclosures break a company into its reportable operating units, revealing revenue, profit, and asset allocation that consolidated financial statements obscure. Under ASC 280, segments must match how the chief operating decision maker views the business, providing a window into internal management structure and resource allocation priorities.

Key signals: compare segment margins to identify which units drive profitability and which destroy value. Watch for changes in the number of reportable segments — segment aggregation or disaggregation often coincides with strategic shifts or attempts to obscure declining performance. Intersegment elimination patterns reveal internal pricing practices. The reconciliation between segment totals and consolidated figures exposes corporate overhead allocation and unallocated items. Geographic revenue concentration highlights regulatory and currency exposure. Compare segment-level capital expenditure against segment revenue to assess where management is investing for future growth versus harvesting existing assets.