Segment
The chief operating decision maker for the Company is the Chief Executive Officer, who reviews financial information presented on a consolidated basis for purposes of allocating resources and assessing financial performance. The Company has a single reporting unit associated with the development and commercialization of diagnostic tests and biopharmaceutical services. The accounting policies of the Company's single segment are the same as those described in the summary of significant accounting policies in Note 2, Summary of Significant Accounting Policies. The chief operating decision maker assesses performance of the Company's single segment and decides how to allocate resources based on consolidated net income. Under the current organizational structure, this measure is not discreetly available or required individually for any of the Company’s business activities and is only available at the consolidated level. The monitoring of budgeted versus actual results are used in assessing performance of the Company's single segment, allocating resources and in establishing management’s compensation. The Company's chief operating decision maker intends for all revenue generating activities to rely on cross-functional activities across the consolidated entity in order to operate. No individual besides the chief operating decision maker has been tasked with reviewing discreet operating results of the business activities, nor is there any intent to bifurcate the overall business review process to produce discreet operating results specific to any of the Company's business activities. The measure of segment assets is reported on the consolidated balance sheet as total consolidated assets. Consolidated revenue does not include any inter-segment sales or transfers.

Information about reported segment revenue, measures of segment profit or loss, significant segment expenses and reconciliation to income from operations was as follows (in thousands):
Year Ended
December 31, 2025December 31, 2024December 31, 2023
Revenue:
Testing revenue$493,154 $418,961 326,542 
Product revenue14,327 13,650 15,588 
Biopharmaceutical and other revenue9,664 13,153 18,921 
Total revenue517,145 445,764 361,051 
Cost of revenue:
Cost of testing revenue:
Laboratory supplies and reagents expense57,284 54,378 42,058 
Sample collection expense12,436 13,868 10,814 
Compensation expense24,611 22,392 18,534 
Other cost of testing revenue (1)19,655 12,147 10,375 
Allocation of facilities and IT expenses13,576 11,788 7,132 
Total cost of testing revenue127,562 114,573 88,913 
Cost of product revenue:
Product costs3,787 3,369 6,362 
License fees and royalties1,206 1,263 1,242 
Other cost of product revenue (2)3,348 3,815 902 
Allocation of facilities and IT expenses466 663 160 
Total cost of product revenue8,807 9,110 8,666 
Cost of biopharmaceutical and other revenue:
Compensation expense3,320 6,015 7,747 
Other cost of biopharmaceutical and other revenue (3)3,333 4,363 5,612 
Allocation of facilities and IT expenses925 2,006 1,965 
Total cost of biopharmaceutical and other revenue7,578 12,384 15,324 
Intangible asset amortization - cost of revenue10,666 11,552 18,464 
Gross profit362,532 298,145 229,684 
Operating expenses:
Research and development:
Compensation expense37,784 37,068 29,180 
Direct research and development expense16,596 19,237 12,918 
Other research and development expenses (4)8,492 6,245 10,280 
Allocation of facilities and IT expenses7,942 6,744 4,927 
Total research and development70,814 69,294 57,305 
Selling and marketing:
Compensation expense69,209 67,662 74,886 
Direct marketing expense5,563 6,283 5,422 
Other selling and marketing expenses (5)14,943 13,488 14,584 
Allocation of facilities and IT expenses10,450 8,001 6,598 
Total selling and marketing100,165 95,434 101,490 
General and administrative:
Compensation expense82,909 74,815 63,769 
Other general and administrative expenses (6)61,234 64,997 43,242 
Allocation of facilities and IT expenses(33,359)(29,202)(20,782)
Total general and administrative110,784 110,610 86,229 
Impairment of long-lived assets20,505 3,368 68,349 
Intangible asset amortization - operating expenses2,487 3,297 2,106 
Other income, net(10,424)(9,602)(9,183)
Income tax provision (benefit)1,848 1,606 (2,208)
Net income (loss)$66,353 $24,138 $(74,404)
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(1)Other cost of testing revenue includes cytopathology services, depreciation and amortization and other expenses.
(2)Other cost of product revenue includes contract manufacturing fees, license fees and royalties, depreciation and amortization and other expenses.
(3)Other cost of biopharmaceutical and other revenue includes license fees and royalties, depreciation and amortization and other expenses.
(4)Other research and development expenses includes depreciation and amortization and other expenses.
(5)Other selling and marketing expenses includes travel, entertainment, conference and other expenses.
(6)Other general and administrative expenses includes professional fees, information technology expense, occupancy costs, depreciation and amortization, contingent consideration and other expenses.

Revenue by geographic region based on the customer billing address was as follows (in thousands):

 Year Ended December 31,
 202520242023
United States$496,598 $423,537 $334,525 
International20,547 22,227 26,526 
Total revenue$517,145 $445,764 $361,051 

Substantially all of the Company’s long-lived assets were located in the United States as of December 31, 2025 and 2024.

About Segments Disclosures

Segment disclosures break a company into its reportable operating units, revealing revenue, profit, and asset allocation that consolidated financial statements obscure. Under ASC 280, segments must match how the chief operating decision maker views the business, providing a window into internal management structure and resource allocation priorities.

Key signals: compare segment margins to identify which units drive profitability and which destroy value. Watch for changes in the number of reportable segments — segment aggregation or disaggregation often coincides with strategic shifts or attempts to obscure declining performance. Intersegment elimination patterns reveal internal pricing practices. The reconciliation between segment totals and consolidated figures exposes corporate overhead allocation and unallocated items. Geographic revenue concentration highlights regulatory and currency exposure. Compare segment-level capital expenditure against segment revenue to assess where management is investing for future growth versus harvesting existing assets.