Property and equipment consisted of the following (in thousands of dollars):

 December 31,
 20252024
Leasehold improvements$12,377 $10,625 
Laboratory equipment36,717 33,729 
Computer equipment7,039 6,959 
Software, including software developed for internal use6,856 6,878 
Furniture and fixtures2,683 4,045 
Construction-in-process— 106 
Total property and equipment, at cost65,672 62,342 
Accumulated depreciation(43,480)(39,389)
Total property and equipment, net$22,192 $22,953 

About PP&E Disclosures

The PP&E disclosure details a company's physical asset base — land, buildings, machinery, and equipment — along with the depreciation methods and useful life assumptions that determine how these costs flow through the income statement. Capitalization policy thresholds reveal management's judgment on the boundary between expense and asset, directly affecting both reported earnings and asset values.

Key signals: changes in estimated useful lives or depreciation methods can materially shift reported earnings without any operational change. Compare capital expenditures against depreciation expense — when capex consistently trails depreciation, the asset base may be aging and underinvested. Watch for large asset impairments or write-downs that signal overvalued carrying amounts. Asset retirement obligations reveal future environmental or decommissioning costs that are often underappreciated. Compare PP&E intensity (PP&E-to-revenue) against industry peers to assess capital efficiency and competitive positioning.