Property and equipment, net consists of the following (in thousands). Depreciation expenses were $11.4 million, $14.2 million, and $18.9 million for the years ended December 31, 2025, 2024 and 2023, respectively.
December 31,
 
Useful life
(in years)
20252024
Leasehold improvements
8 - 12
$56,180 $53,992 
Laboratory equipment540,961 39,428 
Furniture and fixtures52,836 2,696 
Computer equipment32,689 2,778 
Construction in progressNA114 1,074 
Property and equipment, gross102,780 99,968 
Less: accumulated depreciation and amortization(47,160)(36,785)
Total property and equipment, net$55,620 $63,183 

About PP&E Disclosures

The PP&E disclosure details a company's physical asset base — land, buildings, machinery, and equipment — along with the depreciation methods and useful life assumptions that determine how these costs flow through the income statement. Capitalization policy thresholds reveal management's judgment on the boundary between expense and asset, directly affecting both reported earnings and asset values.

Key signals: changes in estimated useful lives or depreciation methods can materially shift reported earnings without any operational change. Compare capital expenditures against depreciation expense — when capex consistently trails depreciation, the asset base may be aging and underinvested. Watch for large asset impairments or write-downs that signal overvalued carrying amounts. Asset retirement obligations reveal future environmental or decommissioning costs that are often underappreciated. Compare PP&E intensity (PP&E-to-revenue) against industry peers to assess capital efficiency and competitive positioning.