Property, equipment and leasehold improvements are stated at cost less accumulated depreciation and amortization calculated using the straight-line method over their estimated useful lives as follows:
Asset classificationEstimated useful life
Laboratory equipment5 years
Computer equipment and software3 years
Office equipment and furniture5 years
Leasehold improvementsLesser of useful life or lease term
Property and equipment, net consisted of the following (in thousands): 
 December 31,
 20252024
Laboratory equipment(1)
$38,943 $35,949 
Leasehold improvements15,229 12,159 
Computer equipment2,556 2,459 
Office furniture and equipment1,133 1,124 
Construction in progress(2)
405 3,441 
Property and Equipment58,266 55,132 
Less: accumulated depreciation(45,242)(40,935)
Property and equipment, net$13,024 $14,197 
(1) Fully depreciated property and equipment with a cost of $0.8 million and $2.6 million were retired during the years ended December 31, 2025 and 2024, respectively.
(2) Construction in progress includes equipment received but not yet placed into service pending installation.
Depreciation expense included in both research and development expenses and selling, general and administrative expenses in the consolidated statements of operations was as follows (in thousands):
 Year Ended December 31,
 202520242023
Research and development$4,125 $3,964 $4,594 
Selling, general and administrative972 881 924 
Total depreciation expense    $5,097 $4,845 $5,518 

Historical Timeline

Fiscal YearFiled
2025Mar 11, 2026Showing above
2024Feb 27, 2025
2023Feb 28, 2024
2022Feb 27, 2023
2021Feb 28, 2022

About PP&E Disclosures

The PP&E disclosure details a company's physical asset base — land, buildings, machinery, and equipment — along with the depreciation methods and useful life assumptions that determine how these costs flow through the income statement. Capitalization policy thresholds reveal management's judgment on the boundary between expense and asset, directly affecting both reported earnings and asset values.

Key signals: changes in estimated useful lives or depreciation methods can materially shift reported earnings without any operational change. Compare capital expenditures against depreciation expense — when capex consistently trails depreciation, the asset base may be aging and underinvested. Watch for large asset impairments or write-downs that signal overvalued carrying amounts. Asset retirement obligations reveal future environmental or decommissioning costs that are often underappreciated. Compare PP&E intensity (PP&E-to-revenue) against industry peers to assess capital efficiency and competitive positioning.