Note 18. Segment Information
We operate in one operating segment, and therefore one reportable segment, focused on the global discovery, development and commercialization of proprietary therapeutics. We manage business activities on a consolidated basis through the development and commercialization of oncology and dermatology products, which are sold to U.S. and international customers. Our determination that we operate as a single operating segment is consistent with the financial information regularly reviewed by the chief operating decision maker for purposes of evaluating performance, allocating resources, setting incentive compensation targets, and planning and forecasting for future periods. Our chief operating decision maker is the Chief Executive Officer.
The accounting policies for our single operating segment are the same as those described in the summary of significant accounting policies. Our single operating segment generates revenues from the development and commercialization of oncology and dermatology pharmaceutical products, which are developed by our research and development department, as well as from product royalties, milestone and contract revenues from the out-licensing of our intellectual property to third parties.
For our segment, the chief operating decision maker uses net income, that also is reported on the consolidated statements of operations as consolidated net income, to allocate resources (including employees, property, and financial resources), predominantly during the annual budget and forecasting process. The chief operating decision maker also uses consolidated net income, along with non-financial inputs and qualitative information, to evaluate our performance, establish compensation, monitor budget versus actual results, and decide the level of investment in our various operating activities and other capital allocation activities. The measure of segment assets is reported on the consolidated balance sheet as total consolidated assets.
Net income for our segment was as follows (in thousands):
Year Ended December 31,
202520242023
Product revenues, net$4,354,333 $3,618,888 $3,165,168 
Product royalty revenues636,909 579,329 523,481 
Milestone and contract revenues150,000 43,000 7,000 
Total revenues5,141,242 4,241,217 3,695,649 
Costs, expenses and other:
Cost of product revenues (including definite-lived intangible amortization)372,130 312,068 254,990 
Contract dispute settlement(242,251)— — 
Research and development - internal1
984,730 957,043 815,025 
Research and development - external2
967,848 866,005 775,919 
Other research and development3
97,574 783,800 36,650 
Sales and marketing1,094,754 945,428 876,703 
General and administrative281,452 296,729 278,959 
Asset impairment76,275 — 5,631 
(Gain) loss on change in fair value of acquisition-related contingent consideration(6,129)19,803 29,202 
(Profit) and loss sharing under collaboration agreements— (1,025)2,045 
Other segment items4
228,209 28,751 22,926 
Net income$1,286,650 $32,615 $597,599 

1.Research and development - internal is comprised of internally generated costs such as salaries, travel, regulatory costs, lab costs, contracting, etc.
2.Research and development - external is comprised of specific program spend with external vendors (i.e. contract manufacturing organization, contract research organization and lab vendors for clinical, technical operations and toxicology services).
3.Other research and development is comprised of all other costs including certain one-time costs resulting from the acquisition of IPR&D assets and one-time development milestone expenses.
4.Other segment items is comprised of interest income, interest expense, realized and unrealized (gain) loss on equity investments, other, net, and provision for income taxes.
Total Revenues by Geographic Location

Total revenues by geographic region consisted of the following (in thousands):
Twelve Months Ended December 31,
202520242023
United States$4,799,941 $3,974,567 $3,514,873 
Europe323,734 260,437 175,866 
Other countries17,567 6,213 4,910 
Total revenues$5,141,242 $4,241,217 $3,695,649 
Property and Equipment, Net by Geographic Location
Property and equipment, net by geographic location was as follows (in thousands):
Dec 31, 2025Dec 31, 2024
United States$406,829 $474,095 
Switzerland309,802 277,623 
Other countries14,254 11,693 
Total property and equipment, net$730,885 $763,411 

Historical Timeline

Fiscal YearFiled
2025Feb 10, 2026Showing above
2024Feb 10, 2025
2023Feb 13, 2024
2022Feb 7, 2023
2021Feb 8, 2022
2020Feb 9, 2021
2019Feb 13, 2020
2018Feb 14, 2019
2017Feb 15, 2018
2016Feb 14, 2017

About Segments Disclosures

Segment disclosures break a company into its reportable operating units, revealing revenue, profit, and asset allocation that consolidated financial statements obscure. Under ASC 280, segments must match how the chief operating decision maker views the business, providing a window into internal management structure and resource allocation priorities.

Key signals: compare segment margins to identify which units drive profitability and which destroy value. Watch for changes in the number of reportable segments — segment aggregation or disaggregation often coincides with strategic shifts or attempts to obscure declining performance. Intersegment elimination patterns reveal internal pricing practices. The reconciliation between segment totals and consolidated figures exposes corporate overhead allocation and unallocated items. Geographic revenue concentration highlights regulatory and currency exposure. Compare segment-level capital expenditure against segment revenue to assess where management is investing for future growth versus harvesting existing assets.