The estimated useful lives by asset classification are generally as follows:
Computer and Office Equipment5 years
Lab Equipment7 years
Leasehold Improvements
Lesser of 15 years or the remainder of the lease
Property and Equipment, net

December 31,
(in thousands)20252024
Lab equipment$93,164 $100,928 
Leasehold improvements70,778 72,727 
Computer and Office equipment
28,692 27,365 
Construction in progress511 2,714 
Property and equipment, gross193,145 203,734 
Less: Accumulated depreciation(89,214)(62,671)
Property and equipment, net$103,931 $141,063 

About PP&E Disclosures

The PP&E disclosure details a company's physical asset base — land, buildings, machinery, and equipment — along with the depreciation methods and useful life assumptions that determine how these costs flow through the income statement. Capitalization policy thresholds reveal management's judgment on the boundary between expense and asset, directly affecting both reported earnings and asset values.

Key signals: changes in estimated useful lives or depreciation methods can materially shift reported earnings without any operational change. Compare capital expenditures against depreciation expense — when capex consistently trails depreciation, the asset base may be aging and underinvested. Watch for large asset impairments or write-downs that signal overvalued carrying amounts. Asset retirement obligations reveal future environmental or decommissioning costs that are often underappreciated. Compare PP&E intensity (PP&E-to-revenue) against industry peers to assess capital efficiency and competitive positioning.