Depreciation is computed using the straight-line method based on the estimated useful lives of the following assets:
Useful Life (Years)
Building3-40
Laboratory equipment and machinery 2-5
Computer equipment2-5
Furniture and fixtures3
Leasehold improvements3-10
Property and equipment, net consisted of the following (in thousands):
December 31,
20252024
Building$147,493 $147,094 
Leasehold improvements89,724 89,567 
Laboratory equipment and machinery78,133 72,498 
Land36,765 36,765 
Computer equipment and software15,281 14,953 
Furniture and fixtures9,850 9,586 
Construction in progress2,929 5,152 
Total property and equipment380,175 375,615 
Less: accumulated depreciation and amortization(153,464)(122,967)
Property and equipment, net$226,711 $252,648 

About PP&E Disclosures

The PP&E disclosure details a company's physical asset base — land, buildings, machinery, and equipment — along with the depreciation methods and useful life assumptions that determine how these costs flow through the income statement. Capitalization policy thresholds reveal management's judgment on the boundary between expense and asset, directly affecting both reported earnings and asset values.

Key signals: changes in estimated useful lives or depreciation methods can materially shift reported earnings without any operational change. Compare capital expenditures against depreciation expense — when capex consistently trails depreciation, the asset base may be aging and underinvested. Watch for large asset impairments or write-downs that signal overvalued carrying amounts. Asset retirement obligations reveal future environmental or decommissioning costs that are often underappreciated. Compare PP&E intensity (PP&E-to-revenue) against industry peers to assess capital efficiency and competitive positioning.