Property and equipment, net consists of the following:

 

 

 

December 31,

 

 

 

2025

 

 

2024

 

 

 

(in thousands)

 

Laboratory equipment

 

$

30,098

 

 

$

25,192

 

Leasehold improvements

 

 

22,278

 

 

 

14,280

 

Computer equipment and software

 

 

7,322

 

 

 

5,046

 

Furniture and fixtures

 

 

1,955

 

 

 

1,200

 

Construction in progress

 

 

54

 

 

 

394

 

 

 

61,707

 

 

 

46,112

 

Less: accumulated depreciation and amortization

 

 

(28,513

)

 

 

(21,823

)

Property and equipment, net

 

$

33,194

 

 

$

24,289

 

About PP&E Disclosures

The PP&E disclosure details a company's physical asset base — land, buildings, machinery, and equipment — along with the depreciation methods and useful life assumptions that determine how these costs flow through the income statement. Capitalization policy thresholds reveal management's judgment on the boundary between expense and asset, directly affecting both reported earnings and asset values.

Key signals: changes in estimated useful lives or depreciation methods can materially shift reported earnings without any operational change. Compare capital expenditures against depreciation expense — when capex consistently trails depreciation, the asset base may be aging and underinvested. Watch for large asset impairments or write-downs that signal overvalued carrying amounts. Asset retirement obligations reveal future environmental or decommissioning costs that are often underappreciated. Compare PP&E intensity (PP&E-to-revenue) against industry peers to assess capital efficiency and competitive positioning.