Property and equipment, net consists of the following:
 December 31,
 20252024
Furniture and fixtures$1,335 $1,598 
Office equipment930 1,127 
Laboratory equipment345 167 
Leasehold improvements (1)
9,925 794 
Manufacturing equipment1,228 604 
Property and equipment, at cost13,763 4,290 
(Less): Accumulated depreciation and amortization(2,098)(1,976)
Property and equipment, net$11,665 $2,314 
(1) This balance represents construction in progress for which no depreciation expense has been recognized.

About PP&E Disclosures

The PP&E disclosure details a company's physical asset base — land, buildings, machinery, and equipment — along with the depreciation methods and useful life assumptions that determine how these costs flow through the income statement. Capitalization policy thresholds reveal management's judgment on the boundary between expense and asset, directly affecting both reported earnings and asset values.

Key signals: changes in estimated useful lives or depreciation methods can materially shift reported earnings without any operational change. Compare capital expenditures against depreciation expense — when capex consistently trails depreciation, the asset base may be aging and underinvested. Watch for large asset impairments or write-downs that signal overvalued carrying amounts. Asset retirement obligations reveal future environmental or decommissioning costs that are often underappreciated. Compare PP&E intensity (PP&E-to-revenue) against industry peers to assess capital efficiency and competitive positioning.